DNA-Based Rabies Vaccine Proves 100% Effective in Test on Monkeys
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Researchers have successfully tested the first DNA-based vaccine against rabies, a virus that has been well-known for thousands of years and now kills 40,000 people worldwide each year. Experiments with macaques, a common variety of large Old World monkey genetically close to humans, showed that the injectable vaccine was 100% effective in protecting the animals against exposure to rabies. Experts said the gene-based vaccine, unlike the vaccine now used, is long-lasting, is inexpensive to make and does not require careful storage and handling. It is ideal for use in developing countries.
On a broader scientific basis, the report in the August issue of Nature Medicine is the best proof yet that a gene-based vaccine can protect against a human pathogen. Researchers said it may provide a blueprint to make similar vaccines against AIDS, hepatitis and other widespread illnesses.
Compiled by Times medical writer Thomas H. Maugh II
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